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Calendar of Physics Talks Vienna
| Mechanical forces guide T-cell activation |
| Speaker: | Marco Fritzsche (MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Headley Way, OX3 9DS Oxford and Kennedy Institute for Rheumatology, Roosevelt Drive, University of Oxford/UK ) |
| Abstract: | Mechanical forces are important for the activation of T cells. Using a suite of advanced quantitative super-resolution imaging and novel force probing methodologies to analyze resting and activated T cells, we demonstrate activating T cells sequentially rearrange their nanoscale mechanobiology, creating a previously unreported ramifying actin network above the immunological synapse (IS). We show evidence that the kinetics of the antigen engaging the T-cell receptor controls the nanoscale actin organisation and mechanics of the IS. Using an engineered T-cell system expressing a specific T-cell receptor and stimulated by a range of antigens, force measurements revealed that the peak force experienced by the T-cell receptor during activation was independent of the kinetics of the stimulating antigen. Conversely, quantification of the actin retrograde flow velocity at the IS revealed a strik |
| Date: | Tue, 31.03.2020 |
| Time: | 16:00 |
| Location: | TU Wien, Institut für Angewandte Physik, E134 1040 Wien, Wiedner Hauptstraße 8-10 Yellow Tower „B“, 5th floor, SEM.R. DB gelb 05 B |
| Contact: | Univ.Prof. Dr. Gerhard Schütz |
| !!! CANCELLED !!! ABGESAGT !!! High intensity cyclotrons for precision neutrino measurements |
| Speaker: | Dr. Daniel Winklehner (MIT) |
| Abstract: | The IsoDAR cyclotron was initially conceived as the high intensity proton driver for neutrino experiments. Either as the injector to an 800 MeV superconducting ring cyclotron for CP violation studies in the neutrino sector or as a standalone driver producing 60 MeV protons for a search for sterile neutrinos. ... Here, I will present the latest beam dynamics results and the technical design of ion source, RFQ and cyclotron, using three novelties. I will describe the IsoDAR experiment, producing neutrinos through isotope decay-at-rest, and how we will make a decisive measurement of light sterile neutrinos within 5 years of running. [complete abstract here: https://indico.smi.oeaw.ac.at/event/360/] |
| Date: | Wed, 01.04.2020 |
| Time: | 17:30 |
| Duration: | 60 min |
| Location: | Stefan-Meyer-Institut, Boltzmanngasse 3, 1090 Wien, Seminarraum 3-2-08 (2. Stock) |
| Contact: | Prof. Dr. Eberhard Widmann, Dr. Martin Simon |
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